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Models

About 42,530 results
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R26-CAG-LSL-hHER2-IRES-Luc-2A-EGFP

모델명：C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-2xpolyA-CAG-LSL-HER2-luciferase-EGFP)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-190008

A SA-2xpolyA-CAG-LSL-HER2-IRES-Luciferase-2A-EGFP-WPRE-polyA cassette was inserted at the Rosa26 locus. When bred to a strain expressing Cre recombinase under control of various tissue specific promoters, Cre recombination deletes the LSL cassette and allows the expression of the HER2 protein.

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hLAG3(BALB/c)

모델명：BALB/cAnSmoc-Lag3em1(hLAG3)/Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-HU-2000051

The endogenous mouse Lag3 gene was replaced by human LAG3 gene.

마우스

Tert-CreERT2-2A-EGFP

모델명：C57BL/6Smoc-Tertem1(CreERT2-2A-GFP-WPRE-PA)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-18037

A CreERT2-2A-GFP-WPRE-PA expression cassette was knocked into the Telt gene start codon site by homologous recombination.

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Piezo1-CreERT2

모델명：C57BL/6Smoc-Piezo1tm2(CreERT2)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-18048

This tamoxifen-inducing Piezo1-CreERT2 tool mouse model was established by inserting a 2A-CreERT2 co-expression cassette into the Piezo1 gene stop codon site .

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hPD-1/hTIM3

모델명：C57BL/6Smoc-Pdcd1em1(hPDCD1)Havcr2em1(hHAVCR2)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-HU-00103

hPD-1(NM-HU-00015) was crossed with hTIM3(NM-HU-00054)to generate hPD-1/hTIM3 mice

마우스

Gad2-IRES-Cre

모델명：C57BL/6Smoc-Gad2em1(IRES-iCre-pA)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-200078

A IRES-iCre-pA expression cassette was knocked into the Gad2 gene stop codon site.

마우스

Abcb4-KO(FVB)

모델명：FVB-Abcb4em1Smoc
모델 상태：Repository Live | 카탈로그：NM-KO-200584

Exon 3-4 of Abcb4 gene was deleted to generate Abcb4 knockout mice.

마우스

hTNFa-Tg

모델명：C57BL/6Smoc-Tgtn(hTNFa promoter-hTNFa-pA)Smoc
모델 상태：Repository Live | 카탈로그：NM-TG-200004

These transgenic mice harbor hTNFa promoter-hTNFa-pA expression cassette.

마우스

Slc6a1-S295L

모델명：C57BL/6Smoc-Slc6a1em2(S295L)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-190014

These mice carry a p.S295L mutation in Slc6a1 gene .

마우스

R26-pAPOE-hCYP3A4(FVB)

모델명：FVB-Gt(ROSA)26Sorem1(pAPOE-CYP3A4)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-18032

This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the liver-specific APOE promoter into the mouse Rosa26 site, which can be used to obtain liver-expressed CYP3A4 humanized model after mating with the Cyp3a13 gene and other Cyp3a family gene knockout mice. This model can be used with NM-KI-18033 mice which has gut-specific expression of human CYP3A4 to compare the contribution of intestinal versus hepatic metabolism to the biotransformation of a test article.

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