Itgam-IRES-DTRGFP
모델명
C57BL/6JSmo-Itgamem1(IRES-DTR-EGFP)Smoc
카탈로그
NM-KI-200066
모델 상태
Repository Live
유전자 요약
Gene Symbol
Itgam
모델 설명
검증 데이터
Fig.1 Schematic representation of dosing regimen. Blood samples were taken from the orbital venous plexus before dosing.
Fig.2 Survival rate of Itgam-IRES-DTRGFP mice treated with DT.
Fig.3 The percent of CD11b+ and other immune cells in peripheral blood of HO Itgam-IRES-DTRGFP mice is detected by FACS.
Myeloid cells were significantly reduced 48 hours (D2) after 1st DT administration, and returned 72 hours (D5) after the 2nd DT treatment. However, macrophages were not significantly cleared after DT treatment.
Fig.4 Detection of GFP expression in mCD11b+/mCD14+/mF4/80+ cells in Peripheral blood in WT C57BL/6 and HO Itgam-IRES-DTRGFP (C57BL/6) KI mice in Day 0.
Fig.5 Detection of GFP expression in mCD11b+/mCD14+/mF4/80+ cells in Peripheral blood in WT C57BL/6 and HO Itgam-IRES-DTRGFP (C57BL/6) KI mice in Day 2.
Fig.6 Detection of GFP expression in mCD11b+/mCD14+/mF4/80+ cells in Peripheral blood in WT C57BL/6 and HO Itgam-IRES-DTRGFP (C57BL/6) KI mice in Day 5.
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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!
At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.
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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
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