Lyz2-IRES-DTRGFP
모델명
C57BL/6JSmo-Lyz2em3(IRES-DTREGFP)Smoc
카탈로그
NM-KI-190041
모델 상태
Repository Live
유전자 요약
Gene Symbol
Lyz2
모델 설명
검증 데이터
Fig1. Analysis of GFP expression by FACS . The Lyz2-DTRGFP mouse expresses GFP on CD11b+ cells.
Fig2. Analysis of the level of different immune cells in PBMC by FACS (See Figure 4 for details of diphtheria toxin injection).
Fig3. Analysis of the level of different immune cells in the spleen and transplanted tumor by FACS (See Figure 4 for details of diphtheria toxin injection).
Fig4. The growth of MC38 tumors in Lyz2-DTRGFP mice and C57BL/6 mice.
Heterozygous Lyz2-DTRGFP mice and C57BL/6 mice were inoculated with MC38 colon cancer cells. The Lyz2-DTRGFP mice were injected with diphtheria toxin twice a week.
The data is provided by Crownbio.
Fig.5 Detection of CD11b, F4/80 and GFP expression in blood of 11-week-old female heterozygous Lyz2-IRES-DTRGFP mice by FACS.
The results showed that EGFP was exclusively detected in CD11b+ cells from LyZ2-IRES-DTRGFP mice; after DT injection, CD11b+ cells and F4/80+ cells decreased dramatically.
Abbr. HE, heterozygous.
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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.
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