Anxa10-2A-CreERT2

모델명

C57BL/6Smoc-Anxa10em1(2A-CreERT2-Wpre-pA)Smoc

카탈로그

NM-KI-200312

모델 상태

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유전자 요약

Official Symbol
Anxa10

Synonyms

NCBI ID

26359

MGI ID

1347090

Ensembl ID

ENSMUSG00000031635

Pubmed

Anxa10

Human Ortholog

ANXA10

모델 설명

2A-CreERT2-Wpre-pA expression cassette was knocked into the Anxa10 gene stop codon site.
신청분야：These mice express tamoxifen induced cre recombinase from the Anxa10 locus. By mating the reporter mice with CreERT2-expressing mice, reporter gene expression can be detected in gastric mucosa epithelial cells after tamoxifen treatment. And the mice are useful for generating conditional mutations in gastric mucosa epithelial cells. This strain may useful for in the research of gastric carcinoma.

검증 데이터

Anxa10-2A-CreERT2-1.png

Fig.1 CreERT2-mediated recombination in the stomach of Anxa10CreERT2/+ ; Rosa26tdTomato/+ mouse. 

TdTomato(red) expression can be detected in the gastric mucosal epithelial cell of Anxa10CreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment. 

Anxa10-2A-CreERT2-2.png

Fig.2 Detection of tdTomato (red) in various tissues of Anxa10CreERT2/+; Rosa26tdTomato/+ mice after tamoxifen treatment. 

CreERT2-mediated recombination in the gastric mucosal cells and hair follicle cells can be induced by tamoxifen. A small degree of leakiness were detected in the thymus prior to tamoxifen exposure. Besides, tdtomato expression can not be detected in the brain, eyes, heart, lung, liver, submandibular gland, kidney, ovary, uterus, intestine, colon, spleen, brown fat, and muscle. (For more detailed information please contact our technical advisor.)

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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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