Ace2-2A-CreERT2

모델명

C57BL/6Smoc-Ace2em2(2A-CreERT2-WPRE-polyA)Smoc

카탈로그

NM-KI-200187

모델 상태

Repository Live

PDF 받기

유전자 요약

Official Symbol
ACE2

Synonyms

ACEH

NCBI ID

59272

MGI ID

Null

Ensembl ID

ENSG00000130234

Pubmed

ACE2

Human Ortholog

ACE2

모델 설명

A 2A-CreERT2-WPRE-polyA expression cassette was knocked into the Ace2 gene stop codon site. Ace2 encodes angiotensin I converting enzyme 2. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Cre. This strain is useful for studying lung injury and kidney disease caused by SARS coronavirus infection.
신청분야：Cre recombinase tool

검증 데이터

image.png

Fig. 1 CreERT2-mediated recombination in the lung of Ace2CreERT2/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the pulmonary bronchial epithelial cells of Ace2CreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment. 

image.png

Fig. 2 CreERT2-mediated recombination in the kidney of Ace2CreERT2/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the proximal tubule of Ace2CreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment. 


당신은 또한 좋아할 수 있습니다

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

조회
Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

조회