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Models

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Slc17a6-IRES-Cre

모델명：C57BL/6Smoc-Slc17a6em1(IRES-iCre)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-200087

A IRES-iCre expression cassette was knocked into the Slc17a6 gene stop codon site.

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hICOSL(2)

모델명：C57BL/6Smoc-Icosltm3(hICOSLG)/Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-HU-2000068

The endogenous mouse Icosl gene was replaced by human ICOSLG gene. While hICOSL(Stock No.NM-HU-00095) mice function similarly to hICOSL(2) mice,for more detailed information please contact our technical advisor.

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hPD-L1/hSIRPA(2)

모델명：C57BL/6Smoc-Sirpatm2(hSIRPA)Cd274em1(hCD274)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-HU-2000099

hPD-L1(NM-HU-00062) was crossed with hSIRPA(2)(NM-HU-18015) to generate hPD-L1/hSIRPA(2).

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R26-CAG-LSL-hEML4/ALK*F1174L-Luc-tdTomato

모델명：C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-2xpolyA-CAG-LSL-EML4-ALK(F1174L)-IRES-luciferase-2A-tdTomato)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-190010

A SA-2xpolyA-CAG-LSL-EML4-ALK(F1174L)-IRES-Luciferase-2A-tdTomato-WPRE-polyA cassette was inserted at the Rosa26 locus. When bred to a strain expressing Cre recombinase under control of various tissue specific promoters, Cre recombination deletes the LSL cassette and allows the expression of the EML4-ALK(F1174L) protein.

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R26-TetO-Dre-IRES-mtagBFP2

모델명：C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-pA-Ins-Ins-TetO-Dre-IRES-BFP-pA-Ins-Ins)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-190020

The SA-polyA-Ins-Ins-TetO-Dre-IRES-BFP-polyA-Ins-Ins cassette is inserted in mouse Rosa26 loci.

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Etv1-CreERT2

모델명：C57BL/6Smoc-Etv1em1(CreERT2-SV40-pA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-200105

A CreERT2 expression cassette was knocked into the Etv1 gene start codon site. ETV1 expression is enriched in fast conduction tissues of embryonic and adult mammalian hearts. And ETV1 expression is upregulated in the atrial tissue of patients with permanent atrial fibrillation. Etv-CreERT2 mice can be applied to heart disease research. ETV1 is also expressed in retinal ganglion cells of adult mice, and the mouse model can be used to study how retinal ganglion cells contribute to visual processing in the brain.

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MHC Class II (I-A/I-E) -KO

모델명：C57BL/6Smoc-H2-Ab1em1H2-Aaem1 H2-Eb1em1H2-Eb2em1H2-Ea-ps em1 Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KO-18032

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models. These MHC class II molecule-deficient mice were on the C57BL/6J genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins.

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Cdk4-KO

모델명：C57BL/6Smoc-Cdk4em1Smoc
모델 상태：Developing | 카탈로그：NM-KO-190614

Exon 3-7 of Cdk4 gene was deleted to generate Cdk4 knockout mice.

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H2/H2-K1-KO(NMG)

모델명：NOD-PrkdcscidIl2rgem1h2em2H2-K1em2Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-NSG-006

Exon 2 of H2;H2-K1 gene was deleted to generate H2;H2-K1 knockout mice.

마우스

Penk-IRES-Cre

모델명：C57BL/6Smoc-Penkem1(IRES2-iCre)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-200088

A IRES2-iCre expression cassette was knocked into the Penk gene stop codon site.

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