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Models

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Apc-L850X

모델명：C57BL/6Smoc-Apcem1(L850X)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-200001

Familial adenomatous polyposis (FAP) is a heritable condition in which affected individuals develop benign intestinal polyps. Often, polyps progress to colorectal carcinomas later in life. The mutation of C57BL/6-Apcem1(L850X)Smoc(NM-KI-200001) strain of SMOC refers to the ApcMin model (Jax: 002020 ), a useful model to study intestinal adenomas. The C57BL/6-Apcem1(L850X)Smoc strain is highly susceptible to spontaneous intestinal adenoma formation and can be used as a research model for human FAP. These mice carry a p.L850X mutation of Apc gene.

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hCD44

모델명：C57BL/6Smoc-Cd44em(hCD44)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-HU-215003

The endogenous mice Cd44 gene was replaced by human CD44 gene.

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Drd2-KO

모델명：C57BL/6Smoc-Drd2em1Smoc
모델 상태：Repository Live | 카탈로그：NM-KO-190265

This Drd2 knockout mouse model was generated by knocking out the exon 3 region of the Drd2.

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Slco1c1-2A-CreERT2

모델명：C57BL/6Smoc-Slco1c1em1(2A-CreERT2)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-200262

2A-CreERT2 expression cassette was knocked into the Slco1c1 gene stop codon site. Slco1c1 encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. When Slco1c1-2A-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in SLCO1C1 positive cells.

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hTROP2

모델명：C57BL/6Smoc-Tacstd2em(hTACSTD2)Smoc
모델 상태：Repository Live | 카탈로그：NM-HU-215022

The endogenous mice Tacstd2 gene was replaced by human TACSTD2 gene.

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hAPOE2

모델명：C57BL/6Smoc-Apoetm4(hAPOE2)Smoc
모델 상태：Repository Live | 카탈로그：NM-HU-190013

This APOE2 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE2 corresponding sequence by homologous recombination.

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Il7r-Cre

모델명：C57BL/6Smoc-Il7rem1(Cre-Wpre-pA)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-200306

Cre-Wpre-pA expression cassette was knocked into the Il7r gene start codon site.

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hPVRIG

모델명：C57BL/6Smoc-Pvrigem1(hPVRIG)/Smoc
모델 상태：Repository Live | 카탈로그：NM-HU-210008

The endogenous mice Pvrig gene was replaced by human PVRIG gene While hPVRIG(2)(Stock No.NM-HU-215013) mice function similarly to hPVRIG mice, for more detailed information please contact our technical advisor.

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R26-CAG-Luc-2A-EGFP

모델명：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-Luc-EGFP)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-00087

This R26-(CAG-Luc-EGFP) strain was generated by crossing R26-(CAG-LSL-Luc-EGFP)(NM-KI-190095) mice with Ddx4-Cre mice.

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hCTLA-4/hTIGIT

모델명：C57BL/6Smoc-Ctla4em1(hCTLA4)Tigitem1(hTIGIT)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-HU-210399

hCTLA4(NM-HU-00014) was crossed with hTIGIT(NM-HU-00053) to generate hCTLA4/hTIGIT mice.

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