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Models

About 42,530 results
마우스

R26-CAG-2xKRAB-dCas9-IRES-EGFP

모델명:C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-Loxp-2xKRAB-dCas9-IRES-EGFP)Smoc
모델 상태:Sperm cryopreservation | 카탈로그:NM-KI-18007

These mice harbor a CAG-LSL-2xKRAB-dCas9-IRES-EGFP-WPRE-pA conditional expression cassette in mouse Rosa26 loci via homologous recombination. This strain can be used in CRISPR mediated target gene transcriptional inhibition (CRISPRi). The loxp-stop-loxp cassette was deleted.

마우스

hPD-1/hPD-L1/hTIM3

모델명:C57BL/6Smoc-Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)Havcr2em1(hHAVCR2)Smoc
모델 상태:Embryo cryopreservation | 카탈로그:NM-HU-200264

hTIM3(NM-HU-00054),hPD-1(NM-HU-00015),hPD-L1(NM-HU-00062)were crossed together to generate hPD-1/hPD-L1/hTIM3 mice

마우스

Ly6g-2A-CreERT2

모델명:C57BL/6Smoc-Ly6gem3(2A-CreERT2)Smoc
모델 상태:Repository Live | 카탈로그:NM-KI-200218

A 2A-CreERT2 expression cassette was knocked into the Ly6g gene start codon site.

마우스

hICOS/hICOSL

모델명:C57BL/6Smoc-Icoslem1(hICOSLG) Icosem1(hICOS)/Smoc
모델 상태:Embryo cryopreservation | 카탈로그:NM-HU-18018

This ICOS and ICOSL double knockin strain is established by crossing ICOS-HU and ICOSL-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

마우스

hTNFR2/hPD-1/hPD-L1

모델명:C57BL/6Smoc-Tnfrsf1bem2(hTNFRSF1B)Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)Smoc
모델 상태:Embryo cryopreservation | 카탈로그:NM-HU-220041

hTNFRSF1B(NM-HU-190010),hPD-1(NM-HU-00015) and hPD-L1(NM-HU-00062) were crossed together to generate hTNFRSF1B/hPD-1/hPD-L1 mice.

마우스

Aire-KO

모델명:C57BL/6Smoc-Aireem1Smoc
모델 상태:Embryo cryopreservation | 카탈로그:NM-KO-2112347

Exon 8 of Aire gene was deleted to generate Aire knockout mice.

마우스

hPD-L1/hTIM3

모델명:C57BL/6Smoc-Cd274em1(hPD-L1)Havcr2em1(hHAVCR2)Smoc
모델 상태:Embryo cryopreservation | 카탈로그:NM-HU-190056

hPD-L1(NM-HU-00062) was crossed with hTIM3(NM-HU-00054) to generate hPD-L1/hTIM3.

마우스

hPD-L1(2)/hCCR8

모델명:C57BL/6Smoc-Cd274em2(hPD-L1)Ccr8em1(hCCR8)/Smoc
모델 상태:Embryo cryopreservation | 카탈로그:NM-HU-210401

hPD-1(2)(NM-HU-190039) was crossed with hCCR8(NM-HU-190053) to generate hPD-L1(2)/hCCR8 mice.

마우스

Tagln-Cre

모델명:C57BL/6Smoc-Taglnem1(Cre-WPRE-polyA)Smoc
모델 상태:Repository Live | 카탈로그:NM-KI-200144

A Cre-WPRE-polyA expression cassette was knocked into the Tagln gene start codon site. This gene encodes a smooth muscle cell-specific cytoskeletal protein. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in vascular smooth muscle cells. In mouse models of atherosclerosis, the gene product may be involved in plaque cell and atherosclerotic lesion formation during atherogenesis.

마우스

hCD3E/hPD-L1

모델명:C57BL/6Smoc-Cd3eem1(hCD3E)Cd274em1(hPD-L1)Smoc
모델 상태:Embryo cryopreservation | 카탈로그:NM-HU-210449

hCD3E(NM-HU-00114) was crossed with hPD-L1(NM-HU-00062) to generate hCD3E/hPD-L1 mice

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