CKO mice developed by SMOC supported the identification of a novel lncRNA that regulates dendritic cell migration and the corresponding immune response
Published on today's Immunity, Prof. Xuetao Cao's group identified a novel long non-coding RNA lnc-Dpf3 whose feedback restrains CCR7-mediated dendritic cell (DC) migration. Mechanistically, CCR7 stimulation activates the HIF-1alpha transcription factor pathway in DCs, leading to metabolic reprogramming towards glycolysis for DC migration.
SMOC generated lnc-Dpf3fl/flItgax-cre+ mice with conditional deletion of this functional lncRNA in DCs, proving that DC-specific lnc-Dpf3 deficiency selectively promotes CCR7-mediated DC migration.
당신은 또한 좋아할 수 있습니다
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.
조회