Fgfr3-G374R
모델명
C57BL/6JSmo-Fgfr3em1G374RSmoc
카탈로그
NM-KI-232354
모델 상태
Sperm cryopreservation
유전자 요약
Gene Symbol
Fgfr3
모델 설명
鉴定报告
Download검증 데이터
Fig.1 Micro-CT analysis of skeleton in 21-day-old WT C57BL/6 mice and HE Fgfr3-G374R mice.
Abbr. WT, wild type; HE, heterozygous.
Fig.2 Micro-CT analysis of skull in 21-day-old Fgfr3-G374R mice.
Significant cranial rounding can be observed in all heterozygous Fgfr3-G374R mice, as indicated by the red circle.
Abbr. WT, wild type; HE, heterozygous.
Fig.3 Analysis of body and various bones length in 21-day-old Fgfr3-G374R mice.
The results revealed significant reductions in R-Op distance in both sexes and in foramen magnum dimensions (length and width) in male Fgfr3-G374R mice, compared to WT controls (n=5-12, Kolmogorov–Smirnov test or Unpaired t-test, *P＜0.05, **P＜0.01, ***P＜0.001, ****P＜0.0001, ns: no significance).
Abbr. WT, wild type; HE, heterozygous; R-Op distance, the linear distance from rhinion to opisthion.
Fig.4 Micro-CT analysis of skeleton in 36-day-old WT C57BL/6 mice and Fgfr3-G374R mice.
Abbr. WT, wild type; HE, heterozygous.
Fig.5 Micro-CT analysis of skull in 36-day-old Fgfr3-G374R mice.
Significant cranial rounding can be observed in all heterozygous Fgfr3-G374R mice, as indicated by the red circle.
Abbr. WT, wild type; HE, heterozygous.
Fig.6 Analysis of body and various bones length in 36-day-old Fgfr3-G374R mice.
The results revealed a shortening of the body, tibia, R-Op distance and foramen magnum length in both sexes of mutant mice. Femoral length was reduced exclusively in mutant males and foramen magnum width was diminished in mutant females (n=5-12, Kolmogorov–Smirnov test or Unpaired t-test, *p＜0.05, **p＜0.01, ***p＜0.001, ****p＜0.0001, ns: no significance).
Abbr. WT, wild type; HE, heterozygous; R-Op distance, the linear distance from rhinion to opisthion.
Fig.7 Representative photographs showing that Fgfr3-G374R mice exhibited a slower growth phenotype compared with WT littermates (n=3, 63 days old).
Abbr. WT, wild type; HE, heterozygous.
Fig.8 Analysis of body weight, brain weight and body lenght of 63-day-old Fgfr3-G374R mice.
The results revealed significant reductions in body weight and body length in male Fgfr3-G374R mice, as well as nose-tail length in female Fgfr3-G374R mice, compared with WT controls. In contrast, brain weight was consistently greater in both male and female Fgfr3-G374R mice, likely reflecting the constitutive activation of FGFR3 caused by the mutation (n=5-12, Kolmogorov–Smirnov test or Unpaired t-test, *P＜0.05, **P＜0.01, ***P＜0.001, ****P＜0.0001, ns: no significance).
Abbr. WT, wild type; HE, heterozygous; R-Op distance, the linear distance from rhinion to opisthion.
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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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