Crbn-I391V
모델명
C57BL/6JSmo-Crbnem1(I391V)Smoc
카탈로그
NM-KI-200331
모델 상태
Repository Live
유전자 요약
Gene Symbol
Crbn
모델 설명
검증 데이터
Fig1. CRBN modulators induced IL-2 secretion and Aiolos degradation in Crbn-I391V point mutation mice.
（A）Analysis of IL-2 production in naive CD4+ T cells by ELISA. After Lenalidomide 5000nM or Pomalidomide 5000nM treatment, CRBN modulators induced IL-2 secretion in naive CD4+ T cells.（B）Analysis of Aiolos expression in the spleen by FACS. After Lenalidomide 10uM or Pomalidomide 5000nM treatment, the AIOLOS expression decreased obviously in CD19+ B cells and CD3+ T cells. The results have shown that this Crbn-I391V KI mice model can be used to study the in vivo toxicity and efficacy of CRBN target drugs. (In collaboration with partners)
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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!
At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.
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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
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