Dmd-Q995X
모델명
C57BL/6JSmo-Dmdem1(Q995X)Smoc
카탈로그
NM-KI-18026
모델 상태
Repository Live
유전자 요약
Gene Symbol
Dmd
모델 설명
검증 데이터
Fig1 Mouse dystrophin expression is abolished due to the p.Q995X mutation.
Fig2 Histopathology of WT and MDX mice(male, 6-month-old) muscle showing less uniform muscle fibers with inflammation and clustered nuclei.
Fig3 Limb grip strength tests in MDX mice.
The assessment of limb strength in experimental mice were performed by means of grip strength meter (BIO-G53, Bioseb, France). The mice were allowed to grab the pull bar and are then gently pulled backwards. The force applied to the bar just before it loses grip was recorded as peak resistance force (expressed in grams). To reduced procedure-related variability, the tests were repeated 4 to 5 times and the average was recorded.
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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!
At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.
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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
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