pAlb-hLPA-Tg(V2)
모델명
C57BL/6JSmo-Tgtn(pAlb-hLPA-3’UTR-pA)1Smoc
카탈로그
NM-TG-231782
모델 상태
Repository Live
모델 설명
검증 데이터
Fig.1 Detection of hLPA expression in serum by ELISA.
Abbr. WT, wild type.
Fig.2 Detection of serum hLPA protein level (A) and inhibiton ratio (B) after single dose of test compound (male, n=5/group). (Data from a collaborator)
Fig.3 Detection of human LPA inhibition by Lepodisiran. Lepodisiran did not induce significant changes in body weight of the pAlb-hLPA-Tg(V2) mice. 6-8-week-old, male pAlb-hLPA-Tg(V2) mice were assigned to four groups for saline or Leposiran (n=5 in each group). Following a single subcutaneous dose in each group, (A) body weight and (B) body weight change were measured.
Fig.4 Detection of human LPA inhibition by Lepodisiran. Lepodisiran significantly reduced serum human LPA levels in a dose-dependent manner. 6-8-week-old, male pAlb-hLPA-Tg(V2) mice were assigned to four groups for saline or Leposiran (n=5 in each group). Following a single subcutaneous dose in each group, (A) serum hLPA levels and (B) hLPA inhibition were measured.
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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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