Hlf-CreERT2

모델명

C57BL/6JSmo-Hlfem1(CreERT2)Smoc

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NM-KI-230441

모델 상태

Sperm cryopreservation

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유전자 요약

Gene Symbol
Hlf

모델 설명

CreERT2 expression cassette was knocked into the Hlf gene .

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Fig1. CreERT2 mediated recombination in liver of HlfCreERT2/+; Rosa26tdTomato/+ mouse. 

R1-8812 HIF-CreERT2.jpgFig2. Detection of tdTomato(red) in various tissues of HlfCreERT2/+; Rosa26tdTomato/+ mouse. 

After tamoxifen induction, tdTomato was expressed in the brain, spinal cord, eyeballs, heart, liver, lungs, stomach, salivary glands, brown adipose tissue, adrenal glands, kidneys, pancreas, large intestine, small intestine, spleen, reproductive organs, muscle, skin, and thymus.

Tissues with expression leakage in the uninduced group: brain, eyeballs, brown adipose tissue, adrenal glands, kidneys, and muscle..(57-days old, male and female) (For more detailed information please contact our technical advisor.) 




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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

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Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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