hCFB
모델명
C57BL/6JSmo-Cfbtm1(hCFB)Smoc
카탈로그
NM-HU-2000078
모델 상태
Repository Live
유전자 요약
Gene Symbol
Cfb
모델 설명
검증 데이터
Fig1. Detection of CFB expression in liver by RT-PCR.
Wild type: only one band at 441 bp with primers F1/R1(mCfb);
Homozygous: only one band at 442 bp with primers F2/R2(hCFB);
Abbr. M, DNA marker; HO, homozygous; WT, wild type.
Fig2. Detection of human and mouse CFB expression in serum by ELISA (n=2).
Abbr. HO, homozygous; WT, wild type.
Note: The mouse CFB ELISA kit cross-reacted with mCFB and humanized CFB.
Fig3. Detection of hCFB expression in serum by ELISA(n=3/group).
Abbr. HO, homozygous; WT, wild type
Fig4. Body Weight(A) and Survival Curve(B) of WT C57BL/6 and HO hCFB mice.
Abbr. HO, homozygous; WT, wild type.
Fig5. Blood Biochemistry of WT C57BL/6 and HO hCFB mice.
Abbr. HO, homozygous; WT, wild type.
Fig6. Detection of liver CFB mRNA remaining at Day 7 (A) and serum protein level (B) after single dose of test drug (n=3/group). (Data from a collaborator)
Fig7.Partial representative pictures of liver and kidney pathology in hCFB knockin mice. No obvious lesions were observed in hCFB knockin mice.
당신은 또한 좋아할 수 있습니다
Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!
At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.
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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
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