hSIGLEC10
모델명
C57BL/6JSmo-Siglecgtm1(hSIGLEC10)/Smoc
카탈로그
NM-HU-2000061
모델 상태
Embryo cryopreservation
유전자 요약
Gene Symbol
Siglecg
모델 설명
검증 데이터
Fig.1 Strain specific analysis of SIGLEC10 gene expression in WT and hSIGLEC10 mice by RT-PCR.
Mouse Siglecg mRNA was detectable in splenocytes of wild-type mice( P1/2 : 812bp). Human SIGLEC10 mRNA was detectable only in homozygous hSIGLEC10 mice (P3/2 : 394bp) , but not in the WT.
M：100bp Plus DNA ladder from Transgen (BM311)
Fig.2 Strain specific SIGLEC10 expression analysis in the CD19+ PBMC or splenocytes of homozygous hSIGLEC10 mice by FACS.
anti-mouse Siglec-G：BD Pharmingen™,563336；
anti-human Siglec-10：Biolegend，347603.
Fig.3 In vivo efficacy study in SIGLEC10 humanized mice grafted with MC38-hCD24 tumor model. CD24 mAb1 and CD24 mAb2 can inhibit the growth of MC38-hCD24 xenografts(A), and have no significant effect on the body weight of hSIGLEC10 mice (B).
당신은 또한 좋아할 수 있습니다
Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!
At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.
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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
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