hPCSK9
모델명
C57BL/6JSmo-Pcsk9tm2(hPCSK9)/Smoc
카탈로그
NM-HU-00075
모델 상태
Repository Live
유전자 요약
Gene Symbol
Pcsk9
모델 설명
검증 데이터
Fig.1 Expression of PCSK9 in the serum of humanized PCSK9 homozygous mice is detected by Elisa. (a) The expression of human PCSK9 can be detected in the serum collected from homozygous mice. (b) The expression of mouse PCSK9 can not be detected in the serum collected from homozygous mice.
Fig.2 Detection of the blood lipid index of (A) TG, (B) TC, (C) HDL-C and (D) LDL-C in chow diet-fed WT mice and HO hPCSK9 mice before treatment. (n=7-8, 6-week-old male mice).
Abbr. WT, wild type; HO, Homozygous; CD, chow diet.
Fig.3 Body weight in chow diet-fed and Evolocumab-treated HO hPCSK9 knockin mice (8 male mice in each group).
Abbr. HO, Homozygous; CD, chow diet.
Fig.4 Detection of the blood lipid index of (A) TG, (B) T-CHO, (C) HDL-C and (D) LDL-C in chow diet-fed and Evolocumab-treated HO hPCSK9 knockin mice.
Blood lipids level of hPCSK9 mice before and after dosing were detected. Data were all normalized to control (8 male mice in each group. Mean ± SEM. *p < 0.05 and **p < 0.01 in Evolocumab group under t-test versus control).
Abbr. HO, Homozygous; CD, chow diet.
Fig.5 Liver weight-to-body weight ratio in chow diet-fed HO hPCSK9 knockin mice after 35 days of dosing (8 male mice in each group).
Abbr. HO, Homozygous; CD, chow diet.
당신은 또한 좋아할 수 있습니다
Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!
At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.
조회Milestones
Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
조회