MHCII/B2m-KO(NMG)
모델명
NOD.Cg-PrkdcscidIl2rgem1SmocH2-Ab1em1SmocH2-Aaem1SmocH2-Eb1em1SmocH2-Eb2em1SmocH2-Ea-psem1SmocB2mem1Smoc
카탈로그
NM-NSG-014
모델 상태
Repository Live
유전자 요약
Official Symbol
B2M
Official Symbol
MHCII(H2-Ab1; H2-Aa; H2-Eb1; H2-Eb2; H2-Ea)
모델 설명
All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models.Also, B2m gene was knocked out. These MHC class I and II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins and B2m of class I.
검증 데이터
Fig1. Detection of MHCII and B2m expression in spleen in MHCII/B2M-dKO (NMG) mice by RT-PCR.
Fig2. Expression characterization of mouse MHC I and MHC II in MHCII/B2M-dKO (NMG) mice.
Fig3. Hematology of MHCII/B2M-dKO (NMG) mice.
Fig4. Blood biochemistry of MHCII/B2M-dKO (NMG) mice.
당신은 또한 좋아할 수 있습니다
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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