Rag2-KO

모델명

C57BL/6JSmo-Rag2em2Smoc

카탈로그

NM-KO-190429

모델 상태

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유전자 요약

Gene Symbol
Rag2

Synonyms

Rag-2

NCBI ID

19374 

MGI ID

97849

Ensembl ID

ENSMUSG00000032864

Pubmed

Rag2

Human Ortholog

RAG2

모델 설명

Partial exon 3 of Rag2 gene was deleted to generate Rag2 knockout mice. Deletion of this region will cause frameshift and result in loss of function of mouse Rag2 gene.
신청분야：Immunodeficiency,tumor-bearing model

검증 데이터

FACS detection of T and B cells collected from Rag2 knockout mice

Figure 1. Loss of T,B cells in Rag2(-/-) mice.

Splenocytes and blood cells of Rag2 knockout mice were isolated. Fractions of T and B cells were characterized using flow-cytometry. 

간행물 2piece

1. Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases
Published year：2021-11-17 References：iScience

2. E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases
Published year：2020-07-01 References：The Journal of Clinical Investigation

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