hIL2RA
모델명
C57BL/6JSmo-Il2ratm1(hIL2RA)Smoc
카탈로그
NM-HU-190064
모델 상태
Repository Live
유전자 요약
Gene Symbol
Il2ra
모델 설명
검증 데이터
Fig1. Detection of IL2RA expression by RT-PCR.
Wild type: only one band at 203 bp with primers F2/R2(mIl2ra);
Homozygous: only one band at 251 bp with primers F1/R1(hIL2RA);
Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.
Fig2. hlL-2RA (hCD25) expresses on naïve CD4+ T cells in blood in hlL2RA knockin mice. (Completed in collaboration with CrownBio)
Fig3. Characterization of hIL2RA knockin mice. (Completed in collaboration with CrownBio)
(A) hlL-2RA is highly expressed on activated Tregsin spleen in IL-2RA humanized mouse; (B)hlL-2RA is highly expressed on activated NK cells in spleen in IL-2RA humanized mouse.
Fig4. In vivo efficacy study in hIL-2RA knockin mice engrafted with MC38 syngeneic tumor model. (Completed in collaboration with CrownBio)
(A)Tumor growth curves upon treatment; (B) Body weight change upon treatment.
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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!
At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.
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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
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