Tubb3-2A-CreERT2-2A-tdTomato
모델명
C57BL/6JSmo-Tubb3em1(P2A-CreERT2-T2A-tdTomato-WPRE-pA)Smoc
카탈로그
NM-KI-240472
모델 상태
Repository Live
유전자 요약
Gene Symbol
Tubb3
모델 설명
鉴定报告
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Fig1. CreERT2 mediated recombination in cerebellum of Tubb3CreERT2/+; Rosa26zsGreen/+ mouse.

Fig2. CreERT2 mediated recombination in DRG of Tubb3CreERT2/+; Rosa26zsGreen/+ mouse.

Fig3. Detection of zsGreen(Green) and tdTomato(red) in various tissues of Tubb3CreERT2/+; Rosa26zsGreen/+ mouse.
Following tamoxifen induction, tissues expressing zsGreen included the brain, spinal cord, reproductive system, skin, pituitary gland and dorsal root ganglia. Tissues with low levels of zsGreen expression included the heart, lung, and liver.
In the absence of tamoxifen induction, low-level leaky expression of zsGreen was observed in the brain, spinal cord, dorsal root ganglia, and pituitary gland.
Regarding tdTomato, minor expression was observed in the brain, while no obvious expression was detected in other tissues.
(31-days old, male) (For more detailed information please contact our technical advisor.)
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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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