Lgr5-2A-DreERT2

모델명

C57BL/6JSmo-Lgr5em1(2A-DreERT2)Smoc

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NM-KI-200178

모델 상태

Sperm cryopreservation

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유전자 요약

Gene Symbol
Lgr5

모델 설명

A 2A-DreERT2 expression cassette was knocked into the Lgr5 gene stop codon site.
신청분야:Dre recombinase tool

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image.png

Fig1. Dre mediated recombination in liver of Lgr5DreERT2/+; Rosa26tdTomato/+ mouse.

Hepatocyte expressing tdTomato(red) after tamoxifen induction of Lgr5DreERT2/+; Rosa26tdTomato/+ mouse. (see the reference). 

image.png

Fig2. Dre mediated recombination in colon of Lgr5DreERT2/+; Rosa26tdTomato/+ mouse.

Lgr5-2A-DreERT2 43T,46.jpg

Fig3. Detection of tdTomato(red) in various tissues of Lgr5DreERT2/+; Rosa26tdTomato/+ mouse. 

Tissues expressing tdTomato after tamoxifen induction included the large intestine, small intestine, liver, stomach, and skin. In contrast, no significant fluorescent expression was observed in the brain, spinal cord, esophagus, muscle, vagina, or reproductive system of the mice following tamoxifen induction. (38-days old, female) (For more detailed information please contact our technical advisor.) 



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