Foxp3-IRES-tdTomato-2A-Cre

모델명

C57BL/6Smoc-Foxp3em3(IRES-tdTomato-2A-iCre)Smoc

카탈로그

NM-KI-190119

모델 상태

Repository Live

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유전자 요약

Gene Symbol
Foxp3

Synonyms

sf; JM2; scurfin

NCBI ID

20371

MGI ID

1891436

Ensembl ID

ENSMUSG00000039521

Pubmed

Foxp3

Human Ortholog

FOXP3

모델 설명

A IRES-tdTomato-2A-Cre expression cassette was knocked into the Foxp3 gene stop codon site. This strain is useful in studying regulatory T cell in autoimmunity, especially in type 1 diabetes.
신청분야：Tool Mice

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Fig1. Detection of tdTomato expression in C57BL/6 and HO Foxp3-IRES-tdTomato-2A-Cre mice.

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Fig2. Cre-mediated recombination in the spleen and thymus of Foxp3Cre/+; Rosa26Zsgreen/+ mouse. Zsgreen(green) expression can be detected in the spleen and thymus of Foxp3Cre/+; Rosa26Zsgreen/+ mouse, while tdTomato(red) expression can not be detected.

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Fig3. Flow cytometry analysis of zsGreen expression in the Foxp3+ cell derived from the thymus of mice. ZsGreen+ cells accounted for 37.56% of Foxp3+ cells in the thymus of Foxp3Cre/+; Rosa26Zsgreen/+ mouse.

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Fig4. Flow cytometry analysis of zsGreen expression in the Foxp3+ cell derived from the spleen of mice. Zsgreen+ cells accounted for 84.74% of Foxp3+ cells in the spleen of Foxp3Cre/+; Rosa26Zsgreen/+ mouse.image.png

Fig5. ZsGreen was also expressed in the mesenteric lymph nodes, pancreas and liver. There was a small amount of expression in the brain, pituitary gland, retina, lung, stomach, kidney, submandibular gland, brown fat, ovary and skin, and no expression in the heart, colon and muscle.（For more information please contact: 400-728-0660.）

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