Nf2-Flox

모델명

C57BL/6Smoc-Nf2tm1(flox)Smoc

카탈로그

NM-CKO-200017

모델 상태

Sperm cryopreservation

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유전자 요약

Official Symbol
Nf2

Synonyms

merlin

NCBI ID

18016

MGI ID

97307

Ensembl ID

ENSMUSG00000009073

Pubmed

Nf2

Human Ortholog

NF2

모델 설명

These mice carry loxP sites flanking exon 2 of Nf2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Nf2 gene.
신청분야：Cancer research

Disease Connection

Renal Cell Carcinoma

Phenotype(s)

MGI:3850478
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Vil1-cre mice.

Reference(s)

Morris ZS, McClatchey AI, Aberrant epithelial morphology and persistent epidermal growth factor receptor signaling in a mouse model of renal carcinoma. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9767-72

Neurofibromatosis

Phenotype(s)

MGI:5619302
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Postn-cre mice.

Reference(s)

Gehlhausen JR, Park SJ, Hickox AE, Shew M, Staser K, Rhodes SD, Menon K, Lajiness JD, Mwanthi M, Yang X, Yuan J, Territo P, Hutchins G, Nalepa G, Yang FC, Conway SJ, Heinz MG, Stemmer-Rachamimov A, Yates CW, Wade Clapp D, A murine model of neurofibromatosis type 2 that accurately phenocopies human schwannoma formation. Hum Mol Genet. 2015 Jan 1;24(1):1-8

Otitis Media

Phenotype(s)

MGI:3850388
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Mpz-cre mice.

Reference(s)

Giovannini M, Robanus-Maandag E, van der Valk M, Niwa-Kawakita M, Abramowski V, Goutebroze L, Woodruff JM, Berns A, Thomas G, Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2. Genes Dev. 2000 Jul 1;14(13):1617-30

Thyroid Gland Cancer

Phenotype(s)

MGI:5784770
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Hras-Flox(NM-CKO-2117376) and TPO-cre mice.

Reference(s)

Garcia-Rendueles ME, Ricarte-Filho JC, Untch BR, Landa I, Knauf JA, Voza F, Smith VE, Ganly I, Taylor BS, Persaud Y, Oler G, Fang Y, Jhanwar SC, Viale A, Heguy A, Huberman KH, Giancotti F, Ghossein R, Fagin JA, NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition. Cancer Discov. 2015 Nov;5(11):1178-93

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