Trp53-KO(2)

모델명

C57BL/6Smoc-Trp53em5Smoc

카탈로그

NM-KO-191203

모델 상태

Embryo cryopreservation

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유전자 요약

Official Symbol
Trp53

Synonyms

bbl; bfy; bhy; p44; p53; Tp53

NCBI ID

22059

MGI ID

98834

Ensembl ID

ENSMUSG00000059552

Pubmed

Trp53

Human Ortholog

TRP53

모델 설명

Exon 5-7 of Trp53 gene was deleted to generate Trp53 knockout mice.
신청분야：Cancer research

Disease Connection

Medulloblastoma

Phenotype(s)

MGI:3818748
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Rag1-KO(NM-KO-2103089) and Xrcc5-KO(NM-KO-202153) mice.

Reference(s)

Holcomb VB, Vogel H, Marple T, Kornegay RW, Hasty P, Ku80 and p53 suppress medulloblastoma that arise independent of Rag-1-induced DSBs. Oncogene. 2006 Nov 16;25(54):7159-65

Malignant Astrocytoma

Phenotype(s)

MGI:5286078
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Nf1-KO(NM-KO-210301) mice.

Reference(s)

Reilly KM, Loisel DA, Bronson RT, McLaughlin ME, Jacks T, Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nat Genet. 2000 Sep;26(1):109-13

Neurofibromatosis

Phenotype(s)

MGI:3580069
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Nf1-KO(NM-KO-210301) mice.

Reference(s)

Vogel KS, Klesse LJ, Velasco-Miguel S, Meyers K, Rushing EJ, Parada LF, Mouse tumor model for neurofibromatosis type 1. Science. 1999 Dec 10;286(5447):2176-9

Medulloblastoma

Phenotype(s)

MGI:3710320
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Cdkn2C-KO(NM-KO-2114003) mice.

Reference(s)

Uziel T, Zindy F, Xie S, Lee Y, Forget A, Magdaleno S, Rehg JE, Calabrese C, Solecki D, Eberhart CG, Sherr SE, Plimmer S, Clifford SC, Hatten ME, McKinnon PJ, Gilbertson RJ, Curran T, Sherr CJ, Roussel MF, The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Genes Dev. 2005 Nov 15;19(22):2656-67

Diffuse Large B-Cell Lymphoma

Phenotype(s)

MGI:5014832

Reference(s)

Slatter TL, Hung N, Campbell H, Rubio C, Mehta R, Renshaw P, Williams G, Wilson M, Engelmann A, Jeffs A, Royds JA, Baird MA, Braithwaite AW, Hyperproliferation, cancer, and inflammation in mice expressing a Delta133p53-like isoform. Blood. 2011 May 12;117(19):5166-77

Li-Fraumeni Syndrome

Phenotype(s)

MGI:2174783

Reference(s)

Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson RT, Weinberg RA, Tumor spectrum analysis in p53-mutant mice. Curr Biol. 1994 Jan 1;4(1):1-7

Li-Fraumeni syndrome

Phenotype(s)

MGI:3584464

Reference(s)

Olive KP, Tuveson DA, Ruhe ZC, Yin B, Willis NA, Bronson RT, Crowley D, Jacks T, Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell. 2004 Dec 17;119(6):847-60

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