hIl5

모델명

C57BL/6JSmo-Il5tm3(hIL5)Smoc

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NM-HU-190001

모델 상태

Embryo cryopreservation

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유전자 요약

Gene Symbol
IL5

모델 설명

This IL5 humanized mouse model was established by replacing the mouse Il5 gene coding exons and introns with the human TLR9 corresponding sequence by homologous recombination.
신청분야:Immune-related

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image.png

Fig1. Detection of IL-5 expression in thymus by RT-PCR. Wild type: only one band at 206 bp with primers F1/R1(mIl-5);Homozygous: only one band at 207 bp with primers F2/R2(hIL-5); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

IL5-Hu.png

Fig 2. Expression of human IL5 in the Serum of IL5-HU homozygous mice is detected by Elisa.

IL5-Mu.png

Fig 3. Expression of murine IL5 in the Serum of IL5-HU homozygous mice is detected by Elisa.


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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

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Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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