F8-KO(2)

모델명

C57BL/6Smoc-F8em3Smoc

카탈로그

NM-KO-200608

모델 상태

Embryo cryopreservation

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유전자 요약

Official Symbol
F8

Synonyms

Cf8; Cf-8; FVIII

NCBI ID

14069

MGI ID

88383

Ensembl ID

ENSMUSG00000031196

Pubmed

F8

Human Ortholog

F8

모델 설명

F8-KO(2) mice (Stock No.NM-KO-200608）carry a knockout allele derived from the targeted deletion of exon 1-26. While F8-KO mice (Stock No.NM-KO-00012) carrying the exon 16-19 deletion.
신청분야：Hemophilia A;HEMA

Disease Connection

factor VIII deficiency

Phenotype(s)

MGI:2449544

Reference(s)

Bi L, Lawler AM, Antonarakis SE, High KA, Gearhart JD, Kazazian HH Jr, Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A [letter]. Nat Genet. 1995 May;10(1):119-21

검증 데이터

4.png

Fig1. Analysis of activated partial thromboplastin time (APTT) in the F8 knock-out mice. The coagulation time in F8-KO(2) (NM-KO-200608) was significantly longer than wild-type, and there was no obvious difference in coagulation time between F8-KO（NM-KO-00012）and F8-KO(2) (NM-KO-200608).


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