Pah-KO

모델명

C57BL/6Smoc-Pahem1Smoc

카탈로그

NM-KO-2110565

모델 상태

Repository Live

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유전자 요약

Official Symbol
Pah

Synonyms

AW106920

NCBI ID

18478

MGI ID

97473

Ensembl ID

ENSMUSG00000020051

Pubmed

Pah

Human Ortholog

PAH

모델 설명

Exon 2-5 of pah gene was deleted to generate pah knockout mice.

Disease Connection

Phenylketonuria

Phenotype(s)

MGI:6715269

Reference(s)

Singh K, et al., CRISPR/Cas9 generated knockout mice lacking phenylalanine hydroxylase protein as a novel preclinical model for human phenylketonuria. Sci Rep. 2021 Mar 31;11(1):7254

검증 데이터

image.png

Fig1. Characterization of WT C57BL/6 and Pah-KO mice. 

(A) The Pah-KO mice showed lower body weights than the WT mice (n=20/group). (B) Summary of blood Phe at various timepoints is shown (n=20/group). (C) Summary of blood Tyr at various timepoints is shown (n=20/group). Note: Data from the third party.

image.png

Fig2. Hair coat color in WT C57BL/6 and Pah-KO mice. 

Hair coat of the Pah-KO mouse is light brown whereas it is dark brown for the WT C57BL/6 mouse.

Note: Data from the third party.

당신은 또한 좋아할 수 있습니다

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

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