Ctnnb1-Flox

모델명

C57BL/6Smoc-Ctnnb1em1(flox)Smoc

카탈로그

NM-CKO-200154

모델 상태

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유전자 요약

Official Symbol
Ctnnb1

Synonyms

Bfc; Mesc; Catnb

NCBI ID

12387

MGI ID

88276

Ensembl ID

ENSMUSG00000006932

Pubmed

Ctnnb1

Human Ortholog

CTNNB1

모델 설명

These mice carry loxP sites flanking exon 2-6 of Ctnnb1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ctnnb1 gene.
신청분야：MicroRNA and CDK-mediated phosphorylation and Cdc6 removal in cardiomyocyte hypertrophy

Disease Connection

Autism Spectrum Disorder

Phenotype(s)

MGI:5812797
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Pvalb-cre mice.

Reference(s)

Dong F, Jiang J, McSweeney C, Zou D, Liu L, Mao Y, Deletion of CTNNB1 in inhibitory circuitry contributes to autism-associated behavioral defects. Hum Mol Genet. 2016 Jul 1;25(13):2738-2751

Ovarian Cancer

Phenotype(s)

MGI:5432226
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Pten-Flox(NM-CKO-18004) and CYP19A1-cre mice.

Reference(s)

Richards JS, Fan HY, Liu Z, Tsoi M, Lague MN, Boyer A, Boerboom D, Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis. Oncogene. 2012 Mar 22;31(12):1504-20

Testicular Granulosa Cell Tumor

Phenotype(s)

MGI:4941746
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Pten-Flox(NM-CKO-18004) and Amhr2-Cre mice.

Reference(s)

Boyer A, Paquet M, Lague MN, Hermo L, Boerboom D, Dysregulation of WNT/CTNNB1 and PI3K/AKT signaling in testicular stromal cells causes granulosa cell tumor of the testis. Carcinogenesis. 2009 May;30(5):869-78

Prostate Cancer

Phenotype(s)

MGI:3836579
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Pbsn-cre mice.

Reference(s)

Pearson HB, Phesse TJ, Clarke AR, K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse. Cancer Res. 2009 Jan 1;69(1):94-101

Urinary Bladder Cancer

Phenotype(s)

MGI:5790500
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Kras-LSL-G12D(NM-KI-190003) and Upk2-cre mice.

Reference(s)

Ahmad I, Patel R, Liu Y, Singh LB, Taketo MM, Wu XR, Leung HY, Sansom OJ, Ras mutation cooperates with beta-catenin activation to drive bladder tumourigenesis. Cell Death Dis. 2011;2:e124

Ovarian Cancer

Phenotype(s)

MGI:5432224
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Kras-LSL-G12D(NM-KI-190003) and CYP19A1-cre mice.

Reference(s)

Richards JS, Fan HY, Liu Z, Tsoi M, Lague MN, Boyer A, Boerboom D, Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis. Oncogene. 2012 Mar 22;31(12):1504-20

ovarian cancer

Phenotype(s)

MGI:5432231
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Kras-LSL-G12D(NM-KI-190003) and Amhr2-Cre mice.

Reference(s)

Richards JS, Fan HY, Liu Z, Tsoi M, Lague MN, Boyer A, Boerboom D, Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis. Oncogene. 2012 Mar 22;31(12):1504-20

Lung Cancer

Phenotype(s)

MGI:5141741
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Fgfr3-Flox(NM-CKO-2101148) and Upk2-cre mice.

Reference(s)

Ahmad I, Singh LB, Foth M, Morris CA, Taketo MM, Wu XR, Leung HY, Sansom OJ, Iwata T, K-Ras and {beta}-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder. Dis Model Mech. 2011 Jul-Aug;4(4):548-55

Ovarian Cancer

Phenotype(s)

MGI:5432223
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with CYP19A1-cre mice.

Reference(s)

Richards JS, Fan HY, Liu Z, Tsoi M, Lague MN, Boyer A, Boerboom D, Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis. Oncogene. 2012 Mar 22;31(12):1504-20

ovarian cancer

Phenotype(s)

MGI:5432232
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Ctnnb1-Flox(NM-CKO-200154) and Amhr2-Cre mice.

Reference(s)

Richards JS, Fan HY, Liu Z, Tsoi M, Lague MN, Boyer A, Boerboom D, Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis. Oncogene. 2012 Mar 22;31(12):1504-20

Otitis Media

Phenotype(s)

MGI:3706580
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with CMV-cre mice.

Reference(s)

Schmidt-Ullrich R, Aebischer T, Hulsken J, Birchmeier W, Klemm U, Scheidereit C, Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices. Development. 2001 Oct;128(19):3843-53

Melanoma

Phenotype(s)

MGI:4418449
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Cdkn2a-Flox(2)(NM-CKO-200151)，Pten-Flox(NM-CKO-18004) and Tyr-cre/ERT2 mice.

Reference(s)

Held MA, Curley DP, Dankort D, McMahon M, Muthusamy V, Bosenberg MW, Characterization of melanoma cells capable of propagating tumors from a single cell. Cancer Res. 2010 Jan 1;70(1):388-97

Urinary Bladder Cancer

Phenotype(s)

MGI:5790498
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Cdkn1a-Flox(NM-CKO-200033) and Upk2-cre mice.

Reference(s)

Ahmad I, Patel R, Liu Y, Singh LB, Taketo MM, Wu XR, Leung HY, Sansom OJ, Ras mutation cooperates with beta-catenin activation to drive bladder tumourigenesis. Cell Death Dis. 2011;2:e124

Salivary Gland Carcinoma

Phenotype(s)

MGI:5508218
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Bmpr1a-Flox(NM-CKO-2100038) and KRT14-cre mice.

Reference(s)

Wend P, Fang L, Zhu Q, Schipper JH, Loddenkemper C, Kosel F, Brinkmann V, Eckert K, Hindersin S, Holland JD, Lehr S, Kahn M, Ziebold U, Birchmeier W, Wnt/beta-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours. EMBO J. 2013 Jul 17;32(14):1977-89

Ovarian Cancer

Phenotype(s)

MGI:5432228
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Amhr2-Cre mice.

Reference(s)

Richards JS, Fan HY, Liu Z, Tsoi M, Lague MN, Boyer A, Boerboom D, Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis. Oncogene. 2012 Mar 22;31(12):1504-20

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