Foxp3-IRES-DTR-2A-tdTomato(BALB/c)

모델명

BALB/cAnSmoc-Foxp3em9(IRES-DTR-2A-tdTomato)Smoc

카탈로그

NM-KI-200213

모델 상태

Embryo cryopreservation

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유전자 요약

Official Symbol
Foxp3

Synonyms

sf; JM2; scurfin

NCBI ID

20371

MGI ID

1891436

Ensembl ID

ENSMUSG00000039521

Pubmed

Foxp3

Human Ortholog

FOXP3

모델 설명

A IRES-DTR-2A-tdTomato expression cassette was knocked into the Foxp3 gene stop codon site.
신청분야：DTR tool mice

검증 데이터

CT 26 tumor cells were injected into FOXP3-DTR mice administered with different treatment, and Balb/c mice, respectively. And tumor growth curves of each group were recorded.

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Fig 1. The growth of CT26 tumors in Foxp3-IRES-DTR-2A-tdTomato mice administered with different treatment and Balb/c mice. (In collaboration with CrownBio)


Proportion of different type-specific T cells and macrophages in peripheral blood of each group analyzed using FACS

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Fig 2. The percentage of different type-specific T cells and macrophages in peripheral blood of CT26 tumor-bearing Foxp3-IRES-DTR-2A-tdTomato mice administered with different treatment and Balb/c mice is detected by FACS. (In collaboration with CrownBio)


Proportion of different type-specific T cells and macrophages in spleen and tumor of each group analyzed using FACS

image.png

Fig 3. The percentage of different type-specific T cells and macrophages in spleen and tumor of of CT26 tumor-bearing Foxp3-IRES-DTR-2A-tdTomato mice administered with different treatment and Balb/c mice is detected by FACS. (In collaboration with CrownBio)

image.png

Fig 4. DTR  mediated cell knockout  in spleen of Foxp3-DTR/tdTomato mice (BALB/c).

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Fig 5. DTR  mediated cell knockout  in mesenteric lymph nodes of Foxp3-DTR/tdTomato mice(BALB/c). 

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