hTNFRSF12A
모델명
C57BL/6JSmo-Tnfrsf12atm(hTNFRSF12A)Smoc
카탈로그
NM-HU-230046
모델 상태
Repository Live
유전자 요약
Gene Symbol
Tnfrsf12a
모델 설명
검증 데이터
Fig.1 Detection of TNFRSF12A expression in adrenal and ovary by RT-PCR. Tissues RNA was extracted from a 11-week-old female WT C57BL/6 mosue and 8-week-old female homozygous hTNFRSF12A knockin mice (n=2), then cDNA libraries were synthesized by reverse transcription, followed by PCR with mRNA primers. Mouse Tnfrsf12a mRNA (135 bp) was detectable only in wild-type C57BL/6 mice. Human TNFRSF12A mRNA (104 bp) was detectable only in homozygous hTNFRSF12A knockin mice but not in wild-type mice.
Abbr. M, marker; HO, homozygous; WT, wild type.
Fig.2 Detection of TNFRSF12A expression in hTNFRSF12A mice by WB. The heart, kidney and skeletal muscle tissue lysates were collected from 11-week-old female WT C57BL/6 mice and 8-week-old female homozygous hTNFRSF12A mice, and then analyzed by western blot with anti-TNFRSF12A antibody. Human TNFRSF12A protein was detectable in heart, kidney and skeletal muscle tissues from hTNFRSF12A knockin mice using an antibody cross-reactive between human and mouse TNFRSF12A.
Abbr. HO, homozygous; WT, wild type; PC, positive control, HT-1080 cells; M, marker.
Note. The arrow indicates the target strip.
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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!
At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.
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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
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