hCD4

모델명

C57BL/6Smoc-Cd4em1(hCD4) Smoc

카탈로그

NM-HU-00115

모델 상태

Embryo cryopreservation

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유전자 요약

Official Symbol
Cd4

모델 설명

The endogenous mouse Cd4 gene was replaced by human CD4 gene .
신청분야:Immunotherapy,cancer research,drug screening

검증 데이터

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Fig 1. Flow cytometric analysis of the T cell subtype proportions in peripheral blood from control and the humanized CD4 mouse model. 

 A Lymphocyte dot plots. The gate for lymphocytes is indicated.   B Statistical analyses of the CD8+ T cell and CD4+ T cell  in the indicated groups. *P<0.05,**P<0.01.

CD4-hu-3.png

CD4-hu-4.png

Fig2. Flow cytometric analysis of the T cell subtype proportions in thymus from control and the humanized CD4 mouse model. A Lymphocyte dot plots. The gate for lymphocytes is indicated.   B Statistical analyses of the CD8+ T cell and CD4+ T cell  in the indicated groups. *P<0.05.

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Fig3. Expression characterization of hCD4 in hCD4 KI mice.


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