hCD73(2)
모델명
C57BL/6Smoc-Nt5etm3(NT5E)Smoc
카탈로그
NM-HU-200009
모델 상태
Embryo cryopreservation
유전자 요약
Official Symbol
NT5E
모델 설명
검증 데이터
Fig1. Detection of NT5E expression in liver and lung by RT-PCR. Wild type: only one band at 221 bp with primers F1/R1(mNt5e);Homozygous: only one band at 285 bp with primers F2/R2(hNT5E); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.
Fig2. Expression of CD73 in the peripheral T cells collected from humanized CD73 mice were detected by FACS. The results showed that the expression of human CD73 can be detected in the peripheral T cells of humanized CD73 mice as same as in Hu-PBMC.
Fig.3 In vivo validation of anti-tumor efficacy in a MC38 tumor-bearing model of humanized CD73 mice. Homozygous humanized CD73 mice were inoculated with MC38 colon cancer cells (expressing human CD73 rather than murine CD73). Mice were grouped when the tumor size was approximately 100 mm3(n=6). Three human CD73 antibodies differently inhibited tumor growth, confirming that the CD73-HU mouse model is a powerful tool for in vivo CD73 antibody pharmacological efficacy study. A.Tumor average volume ± SEM, B.Mice average weight ± SEM.
당신은 또한 좋아할 수 있습니다
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.
조회