Ccr2-IRES-DTRGFP

모델명

C57BL/6Smoc-Ccr2em1(IRES-DTRGFP)Smoc

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NM-KI-210102

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유전자 요약

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Ccr2

모델 설명

IRES-DTRGFP expression cassette was knocked into the Ccr2 gene .

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Fig1. Analysis of GFP expression in the Ccr2-IRES-DTRGFP mice by FACS. The expression of GFP could be detected in CCR2+ and CD11b+ cells in peripheral blood of the heterozygous KI mice.

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Fig2. Analysis of CCR2+/CD11b+ cells proportion and GFP level in Ccr2-IRES-DTRGFP mice by FACS. The heterozygous KI mice were treated with DT (qd x 3 days).After 2 days of drug withdrawal, the proportion of CCR2+ and CD11b+ cells in the peripheral blood were decreased, and the level of GFP positive cells also decreased. After 4 days of drug withdrawal, the proportion of CCR2+ and CD11b+ cells returned to normal, and the level of GFP positive cells also returned to normal.


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