Cd4-IRES-DTRGFP
모델명
C57BL/6Smoc-Cd4em5(IRES-DTREGFP)Smoc
카탈로그
NM-KI-190121
모델 상태
Repository Live
유전자 요약
Official Symbol
Cd4
모델 설명
검증 데이터
Figure 1. EGFP expression analysis in PBMC of CD4-IRES-DTR-EGFP heterozygous mice by FACS. (In collaboration with CrownBio).
Figure2. The percent of CD4+ T cells and other immune cells in peripheral blood of CD4-IRES-DTR-EGFP mice were detected by FACS. (In collaboration with CrownBio)
The C57BL/6 mice and CD4-IRES-DTR-EGFP mice were injected with diphtheria toxin, the results indicated that CD4+ T cells and Tregs of CD4-IRES-DTR-EGFP mice were depleted and meanwhile the amount of CD8+ T cells increased.
Figure3. The growth of MC38 tumors in CD4-IRES-DTR-EGFP mice and C57BL/6 mice. (In collaboration with CrownBio)
Heterozygous CD4-IRES-DTR-EGFP mice and C57BL/6 mice were inoculated with MC38 colon cancer cells. The CD4-IRES-DTR-EGFP mice were injected with diphtheria toxin once in two days.
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.
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