hEPCAM

모델명

C57BL/6Smoc-EpCAMtm1(hEpCAM)Smoc

카탈로그

NM-HU-210032

모델 상태

Sperm cryopreservation

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유전자 요약

Official Symbol
Epcam

모델 설명

The endogenous mice Epcam gene was completely or partially replaced by human EPCAM gene via ESC targeting.
신청분야:inmmue therapy;drug screening

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Fig1. Analysis of mouse EPCAM and human EPCAM protein expression in the large intestine by IHC. Both the EPCAM humanized heterozygous mouse and wild type express mouse EPCAM in the mucosal epithelial membranes, and the humanized heterozygous mouse  expresses human EPCAM in the crypts significantly.

2.pngFig2. Analysis of mouse EPCAM and human EPCAM protein expression in the small intestine by IHC. Both the EPCAM humanized heterozygous mouse and wild type express mouse EPCAM in the mucosal epithelial membranes, and the humanized heterozygous mouse  expresses human EPCAM in the crypts significantly.

image.png

Fig3. Detection of human EpCAM expression in WT C57 and homozygous hEpCAM mice by IHC. Small intestine were collected from wild-type mice (+/+) and homozygous hEpCAM mice (HO/HO), and analyzed by IHC with anti-human EpCAM antibody. 


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