Rag2-KO

모델명

C57BL/6Smoc-Rag2em2Smoc

카탈로그

NM-KO-190429

모델 상태

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유전자 요약

Official Symbol
Rag2

Synonyms

Rag-2

NCBI ID

19374 

MGI ID

97849

Ensembl ID

ENSMUSG00000032864

Pubmed

Rag2

Human Ortholog

RAG2

모델 설명

Partial exon 3 of Rag2 gene was deleted to generate Rag2 knockout mice. Deletion of this region will cause frameshift and result in loss of function of mouse Rag2 gene.
신청분야：Immunodeficiency,tumor-bearing model

Disease Connection

Ulcerative Colitis

Phenotype(s)

MGI:4360989
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Tbx21-KO(NM-KO-190157) mice.

Reference(s)

Garrett WS, Lord GM, Punit S, Lugo-Villarino G, Mazmanian SK, Ito S, Glickman JN, Glimcher LH, Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell. 2007 Oct 5;131(1):33-45

Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive

Phenotype(s)

MGI:2174910

Reference(s)

Shinkai Y, Rathbun G, Lam KP, Oltz EM, Stewart V, Mendelsohn M, Charron J, Datta M, Young F, Stall AM, Alt FW, RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell. 1992 Mar 6;68(5):855-67

검증 데이터

FACS detection of T and B cells collected from Rag2 knockout mice

Figure 1. Loss of T,B cells in Rag2(-/-) mice.

Splenocytes and blood cells of Rag2 knockout mice were isolated. Fractions of T and B cells were characterized using flow-cytometry. 

간행물

E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases
References：The Journal of Clinical Investigation

Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases
References：iScience

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