hF11

모델명

C57BL/6Smoc-F11em1(hF11)/Smoc

카탈로그

NM-HU-210015

모델 상태

Repository Live

PDF 받기

유전자 요약

Official Symbol
F11

모델 설명

The endogenous mice F11 gene was replaced by human F11 gene
신청분야:drug screening

검증 데이터

image.png

Fig1. Detection of F11 expression in liver by RT-PCR. 

Wild type: only one band at 364 bp with primers F1/R1(mF11);Homozygous: only one band at 364 bp with primers F2/R2(hF11); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

image.png

Fig 2. Detection of hF11 expression in plasma by ELISA (RayBiotech, ELH-CoagFXI-1). 

Abbr. HO, homozygous; WT, wild type.

image.png

Fig3. Detection of hF11 expression in plasma by ELISA (Abcam, ab108834). 

Abbr. HO, homozygous; WT, wild type.

image.png

Fig4. Prothrombinogen time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB) in hF11 mice. A. 8-10 weeks of age; B. 10-12 weeks of age.


당신은 또한 좋아할 수 있습니다

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

조회
Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

조회