hHLA-A2.22

모델명

C57BL/6Smoc-H2-D1em1(hHLA-A2)Smoc

카탈로그

NM-HU-204988

모델 상태

Embryo cryopreservation

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유전자 요약

Official Symbol
H2-D1

Synonyms

H-2D; H2-D; H2-K1

NCBI ID

14964

MGI ID

95896

Ensembl ID

ENSMUSG00000073411

Pubmed

H2-D1

Human Ortholog

HLA-A，HLA-B，HLA-C

Official Symbol
H2-D1

Synonyms

H-2D H2-D H2-K1

NCBI ID

14964

MGI ID

95896

Ensembl ID

ENSMUSG00000073411

Pubmed

H2-D1

Human Ortholog

H2-D1

모델 설명

The endogenous mice H2-D1 gene was replaced by human HLA-A2 gene.

검증 데이터

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Fig1. Detection of HLA-A2 expression in spleen and intestine by RT-PCR. Wild type: only one band at 400 bp with primers F1/R1(mH2-D1);Heterozygous: one band at 400 bp with primers F1/R1(mH2-D1) and one band at 664 bp with primers F2/R2(hHLA-A2); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

image.png

Fig2. Expression of hHLA-A2 in blood, spleen, bone marrow and Liver in HLA-A2 KI mice. 

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Fig3. Immunophenotyping in HLA-A2 KI mice.

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Fig4. Immunophenotyping in Blood in HLA-A2 KI mice.

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Fig5. Immunophenotyping in Spleen in HLA-A2 KI mice.

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Fig6. Immunophenotyping in Bone Marrow in HLA-A2 KI mice.

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