hFCRN

모델명

C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-hFcRn)Fcgrtem1/Smoc

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NM-HU-00109

모델 상태

Embryo cryopreservation

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유전자 요약

Official Symbol
FCGRT

Official Symbol
Fcgrt

모델 설명

This FcRn humanized strain is established by mating endogenous mouse Fcgrt gene Knockout mice with R26-hFcRn(FCGRT) Knock-in mice. These FcRn humanized mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations. While hFCRN(2)(Stock No.NM-HU-190070) and hFCRN(3)(Stock No.NM-HU-2000032)mice function similarly to hFCRN mice,for more detailed information please contact our technical advisor.
신청분야:cancer research,Immunotherapy,drug screening

검증 데이터

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Fig1.The expression of mouse FCGRT and human FCGRT in liver was confirmed by western blotting.

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Fig2. PK validation of human antibody (ustekinumab and briakinumab) in FCGRT humanized Mice.



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