hFCGRT(NMG)

모델명

NOD-PrkdcscidIl2rgem1Fcgrtem2(FCGRT)Smoc

카탈로그

NM-NSG-020

모델 상태

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유전자 요약

Official Symbol
Fcgrt

모델 설명

The background of this strain is NMG, and its endogenous Fcgrt gene is replaced with human FCGRT.

신청분야:Immunotherapy,cancer research,drug screening

검증 데이터

image.png

Fig.1 Detection of FCRN expression in kidney by RT-PCR. 

Wild type: only one band at 181 bp with primers F1/R1(mFcgrt);

Heterozygous: one band at 181 bp with primers F1/R1(mFcgrt) and one band at 310 bp with primers F2/R2(hFCGRT). 

Abbr. M, DNA marker; HE, heterozygous; WT, wild type.

image.png

Fig.2 Detection of human FCRN expression in hFCRN (NMG) mice by WB. 

Abbr. M, marker; WT1, wild type, NOD-Scid; WT2, wild type, NMG; HE, heterozygous; PC, positive control, hFCRN (NM-HU-190070).



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