hHBB

모델명

C57BL/6Smoc-Hbb-bt&Hbb-bstm1(hHBB)/Smoc

카탈로그

NM-HU-2000080

모델 상태

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유전자 요약

Official Symbol
Hbb-bt

Official Symbol
Hbb-bs

모델 설명

The endogenous mouse Hbb-bt and Hbb-bs gene was replaced by human HBB gene.

신청분야:Thalassemia research;drug screening

검증 데이터

image.png

Fig.1 Detection of HBB expression in spleen by RT-PCR. 

Wild type: one band at 139 bp with primers F1/R1(mHbb-bt/Hbb-bs) and one band at 178 bp with primers F2/R2(mHbb-bs/Hbb-bt);

Homozygous: only one band at 162 bp with primers F3/R3(hHBB).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig.2 Detection of human HBB expression in hHBB mice by WB. 

Abbr. M, marker; WT, wild type; HO, Homozygous.


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