hDMPK

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C57BL/6Smoc-Dmpktm1(hDMPK)Smoc

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NM-HU-225084

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Dmpk

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The endogenous mouse Dmpk gene was replaced by human DMPK gene.


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Fig.1 Detection of DMPK expression in heart by RT-PCR. 

Wild type: only one band at 259 bp with primers F1/R1(mDmpk);

Homozygous: only one band at 324 bp with primers F2/R2(hDMPK).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig.2 Detection of human DMPK expression in hDMPK knockin mice by WB. 

Abbr. M, marker; WT, wild type; HO, Homozygous; PC, hela cells.

Note. The anti-human DMPK antibody cross-reacted with mouse DMPK and humanized DMPK. Arrow indicates expected molecular weight and asterisk indicates a nonspecific band.


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