hGCGR

모델명

C57BL/6Smoc-Gcgrem(hGCGR)Smoc

카탈로그

NM-HU-215004

모델 상태

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유전자 요약

Official Symbol
Cxcr5

Synonyms

Blr1; Gpcr6; MDR15; CXC-R5; CXCR-5

NCBI ID

12145

MGI ID

103567

Ensembl ID

ENSMUSG00000047880

Pubmed

Cxcr5

Human Ortholog

CXCR5

모델 설명

The endogenous mice Gcgr gene was replaced by human GCGR gene.

검증 데이터

image.png

Fig1. Detection of GCGR expression in liver by RT-PCR. 

Wild type: only one band at 589 bp with primers F1/R1(mGcgr);

Homozygous: only one band at 501 bp with primers F2/R2(hGCGR).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png


Fig2. Detection of hGCGR expression in hGCGR Mice by WB. 

Abbr. M,marker; HO, homozygous; WT, wild type.

Note. The anti-human GCGR Antibody cross-reacted with mouse GCGR and humanized GCGR.

image.png

Fig3. Detection of hGCGR expression in Kidney in hGCGR KI mice

Note. The anti-human GCGR antibody cross-reacted with mouse GCGR and humanized GCGR.

image.png

Fig4. Detection of hGCGR expression in Liver in hGCGR KI mice.

Note. The anti-human GCGR antibody cross-reacted with mouse GCGR and humanized GCGR.



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