hCSF1R(2)
모델명
C57BL/6Smoc-Csf1rem3(hCSF1R)Smoc
카탈로그
NM-HU-190074
모델 상태
Embryo cryopreservation
유전자 요약
Official Symbol
CSF1R
모델 설명
검증 데이터
Fig1. Detection of CSF1R(2) expression in spleen by RT-PCR. Wild type: only one band at 233 bp with primers F1/R1(mCsf1r(2));Homozygous: only one band at 345 bp with primers F2/R2(hCSF1R(2)); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.
Fig2. Detection of hCSF1R expression in blood and bone marrow in hCSF1R(2) KI mice.
Fig3. FPA008 and human CSF-1R test Ab can effectively inhibit the growth of bone marrow cells in hCSF1R mice, confirming that this model is an appropriate platform for human anti-CSF-1R antibody evaluation.（FPA008，BMS，phase II）
Fig4. Dose-dependent effect of huCSF-1R inhibitors on block the proliferation of macrophages in hCSF1R mice.
당신은 또한 좋아할 수 있습니다
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.
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