hFCRN(2)
모델명
C57BL/6Smoc-Fcgrtem2(hFCGRT)Smoc
카탈로그
NM-HU-190070
모델 상태
Repository Live
유전자 요약
Official Symbol
FCGRT
Official Symbol
Fcgrt
모델 설명
검증 데이터
Fig1. Validation of hFCGRT and mFCGRT expression in humanized Fcgrt mice by Western blot. These results showed that hFCGRT can be expressed in the liver and kidney of humanized Fcgrt homozygous and heterozygous mice，while mFCGRT can not be expressed in the humanized Fcgrt homozygous mice.
Fig2. Blood concentration curves of Keytruda in C57BL/6 and hFcRn KI mice. (n=3/time point/group)
Fig3. Blood concentration curves of Cyramza(A) and Keytruda(B) in C57BL/6, hFcRn KI and Fcgrt-KO mice.(n=3/time point/group)
Fig4. In vivo PK profiles of TAA scfv-anti HSA VHH in hALB/hFCRN mice(NM-HU-200278) (female, 10-12weeks, n=3 mice/timepoint), which were generated by crossing hFCRN(NM-HU-190070) with hALB(NM-HU-200003). (In cooperation with the third party).
Fig5. Blood concentration curves of test articles in C57BL/6 and hFcRn/hALB dKI mice(NM-HU-200278) , which were generated by crossing hFCRN(NM-HU-190070) with hALB(NM-HU-200003).(In cooperation with the third party)
당신은 또한 좋아할 수 있습니다
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.
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