hCD38(2)
모델명
C57BL/6Smoc-Cd38em2(CD38)Smoc
카탈로그
NM-HU-190059
모델 상태
Embryo cryopreservation
유전자 요약
Official Symbol
CD38
모델 설명
검증 데이터
Fig1. hCD38 is highly expressed on both B cells and T cells in human PBMC.
Fig2. m/hCD38 is highly expressed on blood and spleen-derived B cells in hCD38 knockin mice.
Fig3. m/hCD38 can be detected on blood-derived T cells in hCD38 knockin mice.
Fig4. m/hCD38 can be detected on spleen-derived T cells in hCD38 knockin mice.
Fig5. In vivo anti-tumor effect of Daratumumab in hCD38 knockin mice. Homozygous humanized CD38 mice were inoculated with E.G7-OVA T lymphoma cells. The results showed: Daratumumab , a drug targeting human CD38, showed a very significant anti-tumor effect , demonstrating that the humanized CD38 mouse model is a good in vivo model for validating the efficacy of antibodies targeting human CD38.（ In cooperation with Crownbio）
Fig6. Binding assay of Daratumumab to hCD38-derived B cells.（ In cooperation with Crownbio）
Fig7. Binding assay of Daratumumab to hCD38-derived T cells.（ In cooperation with Crownbio）
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.
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