hSTING

모델명

C57BL/6Smoc-Tmem173tm2(hTMEM173)Smoc

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NM-HU-190036

모델 상태

Embryo cryopreservation

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유전자 요약

Official Symbol
Tmem173

모델 설명

The endogenous mouse Tmem173 gene was replaced by human TMEM173 gene.
신청분야:Immunotherapy,cancer research,drug screening

검증 데이터

sting-cd4.png

Fig1 The expression of human STING in CD4+ T lymphocytes of humanized STING mice was measured by FACS. In heterozygous humanized STING mice, active expression of human STING was detected in CD4+ T lymphocytes derived from blood, spleen, thymus and lymph node. 

sting-cd8.png

Fig2 The expression of human STING in CD8+ T lymphocytes of humanized STING mice was measured by FACS. In heterozygous humanized STING mice, active expression of human STING was detected in CD8+ T lymphocytes derived from blood, spleen, thymus and lymph node. 

sting-3.png

Fig3 The expression of human STING in the heart and lung cells was measured by FACS. In heterozygous humanized STING mice, active expression of human STING was detected in the heart and lung cells . 


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