hICOS/hICOSL

모델명

C57BL/6Smoc-Icoslem1(hICOSLG) Icosem1(hICOS)/Smoc

카탈로그

NM-HU-18018

모델 상태

Embryo cryopreservation

PDF 받기

유전자 요약

Official Symbol
ICOS

Synonyms

AILIM; CCLP; CRP-1; H4; Ly115

NCBI ID

54167

MGI ID

1858745

Ensembl ID

ENSMUSG00000026009

Pubmed

ICOS

Human Ortholog

ICOS

Official Symbol
ICOSL

Synonyms

B7h; GI50; GL50; B7-H2; LICOS; B7RP-1; GL50-B; ICOS-L; Icoslg; Ly115l; AU044799; BG071784; mKIAA0653

NCBI ID

50723

MGI ID

1354701

Ensembl ID

ENSMUSG00000000732

Pubmed

ICOSL

Human Ortholog

ICOSLG

모델 설명

This ICOS and ICOSL double knockin strain is established by crossing ICOS-HU and ICOSL-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.
신청분야：Immunotherapy,cancer research,drug screening

검증 데이터

image.png

Fig1. Detection of hICOSL expression on activated APCs in hICOSL KI mice and hICOS/hICOSL dKI mice. 

Note. The splenocyte-derived activated APCs were stimulated by LPS in vitro.

image.png

Fig2. Detection of hICOS expression on splenocyte-derived activated T cells in hICOS/hICOSL dKI mice.



당신은 또한 좋아할 수 있습니다

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

조회
Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

조회