Humanized Drug Targets

Humanized mice of drug target genes, such as humanized mice of immune checkpoint genes, for drug screening and drug efficacy evaluation, helping accelerate the development of drugs.

마우스	CAG-hACE2-IRES-Luc-Tg 모델명：C57BL/6Smoc-Tgtn(CAG-human ACE2-IRES-Luciferase-WPRE-polyA)Smoc 모델 상태：Repository Live \| 카탈로그：NM-TG-200002 신청분야：corona virus related research
마우스	Fcgr2b-Fcgr3-Fcgr4-KO/hCTLA-4 모델명：C57BL/6Smoc-Fcgr2b^em1Fcgr3^em1Fcgr4^em1Ctla4^{em1(hCTLA4)Smoc} 모델 상태：Sperm cryopreservation \| 카탈로그：NM-KO-220069 신청분야：Immunotherapy,cancer research,drug screening
마우스	Fcgr2b-Fcgr3-Fcgr4-KO/hPD-1 모델명：C57BL/6Smoc-Fcgr2b^em1Fcgr3^em1Fcgr4^em1Pdcd1^{em1(hPDCD1)Smoc} 모델 상태：Sperm cryopreservation \| 카탈로그：NM-KO-220068 신청분야：Immunotherapy,cancer research,drug screening
마우스	Fcgr2b-Fcgr3-Fcgr4-KO/hPD-1/hCTLA-4 모델명：C57BL/6Smoc-Fcgr2b^em1Fcgr3^em1Fcgr4^em1Pdcd1^em1(hPDCD1)Ctla4^{em1(hCTLA4)Smoc} 모델 상태：Sperm cryopreservation \| 카탈로그：NM-KO-220070 신청분야：Immunotherapy,cancer research,drug screening
마우스	H11-pAlb-hALB-IRES-Luc 모델명：C57BL/6Smoc-Igs2^{em1(ALB promoter-human ALB-IRES-Luciferase-polyA)Smoc} 모델 상태：Embryo cryopreservation \| 카탈로그：NM-KI-200322
마우스	H11-pT3(b)-hIL15-Flag 모델명：C57BL/6Smoc-Igs2^{em(pT3(b)-Kozak-hIL2 signal peptide-hIL15-Flag-polyA-pT3(b)-Kozak-hIL2 signal peptide-hIL15-Flag-polyA)Smoc} 모델 상태：Sperm cryopreservation \| 카탈로그：NM-KI-220128
마우스	h4-1BB(2) 모델명：C57BL/6Smoc-Tnfrsf9^{tm2(TNFRSF9)Smoc} 모델 상태：Repository Live \| 카탈로그：NM-HU-190077 신청분야：Immunotherapy,Cancer research,Drug screening
마우스	h4-1BB(2)/hCD3E(2) 모델명：C57BL/6Smoc-Tnfrsf9^tm2(TNFRSF9)Cd3e^{em2(hCD3E)Smoc} 모델 상태：Embryo cryopreservation \| 카탈로그：NM-HU-210409 신청분야：Drug Screening; Immunotherapy Evaluation
마우스	h4-1BB(2)/hOX40 모델명：C57BL/6Smoc-Tnfrsf9^tm2(TNFRSF9)Tnfrsf4^{em1(hTNFRSF4)/Smoc} 모델 상태：Embryo cryopreservation \| 카탈로그：NM-HU-200272
마우스	h4-1BB(2)/hPD-1 모델명：C57BL/6Smoc-Tnfrsf9^tm2(h4-1BB)Pdcd1^{em1(hPDCD1)Smoc} 모델 상태：Embryo cryopreservation \| 카탈로그：NM-HU-200279

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